Effects of acute ischemia on the restitution curves of myocardial tissue: a simulation study

L Romero, J.M. Ferrero, J. Saiz, B. Trenor, M Monserrat, J.M. Alonso, G. Molto, and F Montilla. Effects of acute ischemia on the restitution curves of myocardial tissue: a simulation study. In Computers in Cardiology, 2004, pp. 525–528, IEEE, 2004.

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Abstract

The Electrical Restitution Curve (ERC) may play an important role in the generation and maintenance of Ventricular fibrillation (VF). As VF usually appears in ischemic hearts, we have studied the changes exerted by acute ischemia in ERCs using computer simulations. Our results show that the main effects of ischemia on the ERC are that (a) it shifts the ERC towards lower action potential durations (APDs) and (b) it significantly reduces the slope of the ERC. These findings are in accordance with experimental observations. When analyzing ionic currents, it became clear that, as expected, the slow component of the delayed K current (IKs) was responsible for the slope of the ERC in normal conditions. However, an increased Ca inward current (ICaL) provoked by the altered [Ca2+]i dynamics accounted for the flattening of the ERC in ischemia.

BibTeX Entry

@inproceedings{Romero2004eai,
   abstract = {The Electrical Restitution Curve (ERC) may play an important role in the generation and maintenance of Ventricular fibrillation (VF). As VF usually appears in ischemic hearts, we have studied the changes exerted by acute ischemia in ERCs using computer simulations. Our results show that the main effects of ischemia on the ERC are that (a) it shifts the ERC towards lower action potential durations (APDs) and (b) it significantly reduces the slope of the ERC. These findings are in accordance with experimental observations. When analyzing ionic currents, it became clear that, as expected, the slow component of the delayed K current (IKs) was responsible for the slope of the ERC in normal conditions. However, an increased Ca inward current (ICaL) provoked by the altered [Ca2+]i dynamics accounted for the flattening of the ERC in ischemia.},
   author = {L Romero and J.M. Ferrero and J. Saiz and B. Trenor and M Monserrat and J.M. Alonso and G. Molto and F Montilla},
   doi = {10.1109/CIC.2004.1442990},
   isbn = {0-7803-8927-1},
   booktitle = {Computers in Cardiology, 2004},
   pages = {525-528},
   publisher = {IEEE},
   title = {Effects of acute ischemia on the restitution curves of myocardial tissue: a simulation study},
   url = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=1442990},
   year = {2004}
}